Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis.

نویسندگان

  • Xin Shen
  • Guo-miao Shen
  • Jie Wu
  • Xiao-hong Gui
  • Xia Li
  • Jian Mei
  • Kathryn DeRiemer
  • Qian Gao
چکیده

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

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Detection of Ethambutol-Resistant Associated Mutations in Mycobacterium tuberculosis Isolates from Iran Using Multiplex Allele-Specific PCR

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 51 7  شماره 

صفحات  -

تاریخ انتشار 2007